For each gene, you can search for

  1. CREB binding on the promoter (ChIP-on-chip data);
  2. Presence of CRE (cAMP-repsonse element) on the promoter (promoter sequence analysis result);
  3. Induction by cAMP in specific tissues (Affymetrix gene profiling data).

To start, enter the gene symbol (e.g. HDAC6), gene ID (e.g. 10013), or gene name (e.g. histone deacetylase 6) and click search.
Tip 1: Please use the official gene symbol or gene ID (locuslink number) from NCBI . You can use Entrez Gene to get the symbol or geneID of your favorite gene. (New) We are now a NCBI LinkOut resource provider, you can go directly from NCBI Entrez gene to our database using the linkout feature.
Tip 2: To browse a table, type "all" for query and all genes will be shown at 30 genes/page. If you only want to look at the best CREB target genes in a table, type the magic word "CREBtarget" as query.
Take a quick tour for how to use the database and how to interpret the result

Search human genes:

Table: Field: Query:       

 

Search mouse genes:

Table: Field: Query:       

 

Search rat genes:

Table: Field: Query:       

 

For further details, please check our PNAS paper:

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
Xinmin Zhang, Duncan T. Odom, Seung-Hoi Koo, Michael D. Conkright, Gianluca Canettieri , Jennifer Best, Huaming Chen, Richard Jenner, Elizabeth Herbolsheimer, Elizabeth Jacobsen, Shilpa Kadam, Joseph R. Ecker, Beverly Emerson, John B. Hogenesch, Terry Unterman, Richard A. Young, and Marc Montminy
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4459-64. Epub 2005 Mar 7.

last updated: 6pm, May 02, 2005
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